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(RTTNews) - Cell Therapeutics, Inc. (CTIC: News ) announced the preliminary results of a phase II study of paclitaxel poliglumex, or OPAXIO, combined with temozolomide, or TMZ, and radiotherapy, or RT, in patients with newly diagnosed high-grade gliomas.

According to the company, in the current study, 25 patients were enrolled with confirmed high-grade glioma, 17 had GBM or gliosarcoma. Patients received PPX with TMZ and RT for six weeks. The main toxicity was grade 4 thrombocytopenia and neutropenia in 6/25 patients, 5 patients of which were receiving concomitant medications which are known to be associated with thrombocytopenia; only 1 of 14 patients not receiving these concomitant medication developed grade 4 thrombocytopenia with PPX in combination with TMZ.

Among the 22 evaluable patients, the overall response rate was 45% (10 of 22) with 27% (6 of 22) of patients achieving a complete response. With a median follow up of 10.2 months, 76% of patients remained free from disease progression or death at 6 months, the company added

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Don